β-cateninC429SmiceexhibitsterilityduetosustainedWntsignalingintheinternalgenitalia.ThismutationleadstocontinuousactivationoftheWntpathway,disruptingnormalreproductivefunction.ThesterilityresultsfromthespatiotemporalpersistenceofWntsignaling,whichinterfereswiththeproperdevelopmentandfunctionoftheinternalgenitalia.ThismodelprovidesinsightsintotheroleofWntsignalinginreproductivebiologyandhighlightstheimportanceofpreciseregulationofthispathwayforfertility.
