TheDelta4geneplaysacrucialroleincellulardifferentiationprocesses,particularlyinhematopoieticcellssuchasthe32Dcellline.AsamemberoftheNotchsignalingpathway,Delta4actsasaligandthatinteractswithNotchreceptorstoregulatecellfatedecisions,proliferation,anddifferentiation.Inthecontextof32Dcells—amurinemyeloidprogenitorcellline—Delta4-mediatedNotchsignalinghasbeenshowntoinfluencegranulocyticandmyeloiddifferentiation.StudiessuggestthatmodulationofDelta4expressioncaneitherpromoteorinhibitdifferentiation,dependingonthecellularcontextandsignalingcrosstalkwithotherpathways.UnderstandingthefunctionofDelta4in32Dcellsprovidesinsightsintohematopoieticdevelopmentandpotentialtherapeutictargetsfordifferentiation-relateddisorders.
