ThePDZ-containingscaffoldisacrucialstructuralcomponentassociatedwiththedystrophincomplex,primarilylocalizedatthebasolateralmembraneofepithelialcells.Thisscaffoldplaysavitalroleinmaintainingcellularintegrityandfacilitatingsignaltransductionbyorganizingprotein-proteininteractions.ThroughitsPDZdomains,itbindstospecifictargetproteins,ensuringproperlocalizationandfunctionofthedystrophincomplex.Thisinteractionisessentialforstabilizingthemembrane,regulatingiontransport,andmaintainingtissuearchitectureinepithelialcells.Dysfunctionofthisscaffoldcanleadtodisruptionsincellpolarityandadhesion,potentiallycontributingtovariousepithelial-relateddisorders.
