Effect of the anti-neoplastic agents edelfosine (ET-18-OCH(sub)3(sub), ilmofosine (BM 41.440) and the hexadecylphosphocholine

Theanti-neoplasticagentsedelfosine(ET-18-OCH3),ilmofosine(BM41.440),andhexadecylphosphocholinerepresentaclassofsyntheticalkylphospholipidswithpromisingantitumoractivity.Thesecompoundsexhibitselectivecytotoxicityagainstcancercellsbytargetingcellmembranecomponentsanddisruptingkeysignalingpathwaysinvolvedincellproliferationandsurvival.Edelfosine,oneofthefirstcompoundsinthisclass,hasdemonstratedefficacyinpreclinicalstudies,whileilmofosineandhexadecylphosphocholinehavealsoshownpotentialasnovelchemotherapeuticagents.Theiruniquemechanismofaction,whichdiffersfromtraditionalDNA-targetingdrugs,makesthemparticularlyinterestingforovercomingdrugresistanceinvariousmalignancies.Researchontheseagentscontinuestoexploretheirtherapeuticpotential,safetyprofiles,andpossiblecombinationswithconventionaltreatments.