TheANP-NPRAsignalingpathwayplaysacrucialroleinregulatingcardiovascularandrenalfunctions,butrecentstudieshaverevealeditspotentialinvolvementincancerprogression.Thispathway,mediatedbyatrialnatriureticpeptide(ANP)anditsreceptorNPRA,influencescellproliferation,apoptosis,andangiogenesis.EmergingevidencesuggeststhatdysregulationoftheANP-NPRAaxismaycontributetotumorgrowthandmetastasisinvariousmalignancies.Researchersarenowexploringthispathwayasanoveltherapeutictarget,withpotentialapplicationsindevelopinganti-cancerdrugs.UnderstandingthemolecularmechanismsofANP-NPRAsignalingcouldopennewavenuesfortargetedcancertherapies,particularlyfortumorsresistanttoconventionaltreatments.Thisreviewfocusesoncurrentknowledgeaboutthepathway'sroleinmalignancyanditstherapeuticimplications.
