Lysosomalmembraneproteinsplaycrucialrolesinmaintaininglysosomalfunctionandcellularhomeostasis.Twosuchproteins,LGP85andLGP107,areknowntobetransportedtolateendosomesandlysosomesviadistinctintracellularpathways.Thesedifferencesintraffickingrouteshighlightthecomplexityofproteinsortingmechanismswithintheendosomal-lysosomalsystem.Understandingtheiruniquedeliverypathwaysprovidesinsightsintolysosomalbiogenesisandmayhaveimplicationsforlysosome-relateddisorders.