Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sj gren's syndrome and other systemic

Inositol1,4,5-trisphosphatereceptors(IP3Rs)havebeenidentifiedasautoantibodytargetantigensinpatientswithSjögren'ssyndromeandothersystemicautoimmunedisorders.ThisfindinghighlightsthepotentialroleofIP3Rsinthepathogenesisoftheseconditions,asautoantibodiesagainstthesereceptorsmaydisruptintracellularcalciumsignalingandcontributetodiseaseprogression.UnderstandingtheinvolvementofIP3Rsinautoimmuneresponsescouldprovidenewinsightsintodiseasemechanismsandopenavenuesfortargetedtherapeuticinterventions.FurtherresearchisneededtoelucidatethepreciseroleoftheseautoantibodiesandtheirclinicalimplicationsinSjögren'ssyndromeandrelatedsystemicautoimmunediseases.