731LossonDryingisatestmethoddescribedintheUnitedStatesPharmacopeia(USP)andNationalFormulary(NF)undertheUSP41-NF36edition.Thistestisusedtodeterminetheamountofvolatilesubstances,suchaswaterorsolvents,thatarelostfromasamplewhenitisdriedunderspecifiedconditions.Theprocedureinvolvesheatingthesampleundercontrolledtemperatureandtimeuntilaconstantweightisachieved.Thedifferenceinweightbeforeandafterdryingrepresentsthelossondrying(LOD).Thistestiscommonlyappliedtopharmaceuticals,excipients,andothersubstanceswheremoisturecontentorresidualsolventsmayaffectproductquality,stability,orperformance.USP41-NF36providesdetailedguidelinesforconductingthetest,includingacceptabledryingmethods(e.g.,ovendrying,infrareddrying,orvacuumdrying),temperaturesettings,andsamplepreparationrequirements.Compliancewiththisstandardensuresconsistencyandreliabilityindeterminingthemoistureorvolatilecontentofmaterialsinthepharmaceuticalindustry.
